Failure to lower liver transaminases may be related to fatty liver, alcohol, drugs, viral infections, cirrhosis and biliary tract diseases. 1. Obesity due to high-fat diet and no exercise causes steatosis of the liver, also known as fatty liver, which will lead to liver aminotransferases not coming down. 2. Long-term alcohol consumption leads to alcoholic hepatitis or even alcoholic cirrhosis, and the liver function test suggests that the transaminase is elevated. 3. Long-term use of certain drugs can also lead to liver aminotransferases can not come down, such as atorvastatin calcium tablets. 4. Hepatitis virus infection leads to acute and chronic hepatitis, such as hepatitis B, which can lead to elevated aminotransferases, which cannot be lowered. 5. If alcoholic hepatitis or viral hepatitis develops further, it will lead to cirrhosis of the liver or even liver cancer, which will lead to liver transaminase not coming down. 6. Biliary tract diseases such as cholecystitis, pancreatitis, periampullary carcinoma, etc. can also lead to liver transaminases not coming down. Therefore, when you find that the liver transaminase does not come down, you should consult a doctor in time, and after clarifying the cause of the disease, you should have a reasonable treatment.