TPPA is also known as syphilis spirochete particle agglutination test, which is a test for syphilis, detecting the presence or absence of syphilis antigens in the blood, and is a confirmatory test for syphilis. To determine the specific status of a patient with syphilis, the RPR test is also required, and only when both tests are positive can it be determined that the patient is in a pathogenic state. However, if a patient is diagnosed as TPPA positive, it can be concluded that the patient was infected, has been infected or is being infected with the syphilis spirochete. TPPA positivity can last a lifetime, even if the patient is cured of syphilis. However, there are a small number of false positives for TPPA positivity, and the chance of these false positives is usually less than 1%.