A high white blood cell count on a lumbar puncture means that there may be inflammation in the cerebrospinal fluid caused by bacterial infection, resulting in a high white blood cell count. If the high level is significant, the infection may be very severe, possibly due to meningitis or traumatic brain injury resulting in an open wound or skull base fracture, resulting in an intracranial infection caused by nasal, oral, or external bacteria entering the brain tissue through the fracture, which may also lead to an elevated leukocyte count in the cerebrospinal fluid. In addition, it may be a stressful reaction to brain or spinal injury, but the elevation is not high, but mild, and the possibility of intracranial infection can be ruled out by rechecking 1-2 days after regular treatment.