Excessive renal excretion of potassium is commonly associated with long-term use of diuretics or excessive dosage. Long-term use of thiazide diuretics may lead to water and electrolyte disturbances, producing hyponatremia, hypochlorhydria and hypokalemia. So, what other causes of excessive potassium excretion may be caused? The following are some of the causes: 1. Potassium loss through the gastrointestinal tract: This is the most important cause of potassium loss in children, and is commonly seen in patients with severe diarrhea and vomiting accompanied by a large loss of digestive juices. In severe vomiting, the loss of gastric juice is not the main cause of potassium loss, but a large amount of potassium is lost via the kidneys with urine, because the metabolic alkalosis caused by vomiting can increase renal potassium excretion, and the reduction in blood volume caused by vomiting can also promote renal potassium excretion through secondary aldosterone increase. 2. Transrenal potassium loss: This is the most important cause of potassium loss in adults. The common factors that cause increased renal potassium excretion are: (1) long-term continuous use or excessive dosage of diuretics; (2) certain renal diseases; (3) excessive adrenocorticotropic hormones; (4) increased anions that are not easily reabsorbed in the distal tubules; (5) magnesium deficiency; (6) alkalosis. 3, through the skin loss of potassium: sweat contains only 9mmol / L. In general, sweating does not cause hypokalemia. However, in a hot environment with heavy work, a lot of sweating can lead to loss of potassium. For patients who excrete too much potassium, especially those who fast, they should be supplied with sugar and liquid by infusion, and if they have urine, they should be given potassium in time. 0.2 g/(kg.d); not too early, see urine potassium supplementation, not premature potassium supplementation when renal insufficiency is not corrected.