High creatinine has various causes, most of which are chronic renal failure. When using medication, we need to clarify the primary cause of high creatinine, such as chronic glomerulonephritis, diabetic nephropathy, etc. Different causes are treated differently. Chronic renal impairment is mainly treated with traditional Chinese medicine, which requires clearing heat and detoxification, activating blood circulation and draining turbidity, and is represented by Yi Qi Kidney Capsules and Descending Turbidity and Detoxification Capsules. Yi Qi Kidney Capsules have the effect of tonifying Qi, invigorating Blood, benefiting Qi and supporting the righteousness, and the main ingredients are Cordyceps Sinensis and Astragalus. Descending turbidity and detoxification capsule can invigorate blood, help the kidney recover and expel toxins. Western medicine treatment needs to control complications and primary diseases, diabetic patients should control blood sugar; hypertensive patients should strictly control blood pressure; patients with chronic renal failure with anemia need to apply blood tonic drugs, such as folic acid, iron, vitamin B12, erythropoietin; with osteoporosis can be treated with osteotriol drugs, active vitamin D3. Therefore, after the increase of blood creatinine, it is necessary to go to the regular hospital for regular medication to reduce the occurrence of complications and delay the renal failure.