Many people have questions about whether gallbladder stones require surgery, when to operate, and what is the better procedure. In principle, gallbladder stones should be removed surgically to prevent acute cholecystitis or other serious complications caused by gallbladder stones, such as acute cholecystitis, common bile duct stones, acute cholangitis, and acute pancreatitis. Generally speaking, there is no need for immediate cholecystectomy for asymptomatic gallbladder stones (note: it means no immediate surgery is needed, but elective surgery is preferable), but timely cholecystectomy is needed if one of the following conditions occurs (1), combined with diabetes —— if the complication of acute cholecystitis, the morbidity and mortality rate is more than 5 times higher; (2), large stones (2-3cm), a large number, especially the longer-term gallbladder stones, the risk of gallbladder cancer; (3), older (> 60 years old), with hypertension or cardiac insufficiency because once the complication of gallbladder stones, the morbidity and mortality rate is extremely high; (4), porcelain (4), porcelain gallbladder, 50% of combined gallbladder cancer, early removal is appropriate; (5), remote mountainous areas, poor medical conditions, should be early prophylactic resection. Once serious complications such as acute cholecystitis or acute pancreatitis occur, they are often unpredictable due to untimely treatment. Laparoscopic cholecystectomy (commonly known as “eyelet”) is currently the classic procedure for gallbladder disease and is the first choice. However, there are some patients who are not suitable for “beating eyes” and need open cholecystectomy, mainly in the following two cases: (1) suspected or confirmed malignant gallbladder lesions; (2) history of complex surgery in the upper abdomen and serious intra-abdominal adhesions.