In the case of picc, i.e., central venous cannulation via peripheral vein puncture, the constant oozing of blood from the eye of the needle may be a normal phenomenon and does not require special treatment. It may also be due to infection and prompt medical attention is recommended. It may be normal for a patient to bleed all the time when using a peripheral venepuncture central venous cannula. When the peripheral venepuncture central venous cannula enters the vein, it stimulates the body and can cause the patient to bleed all the time. If the patient is bleeding heavily, this may be due to an infection at the needle eye, and the patient may also experience redness, swelling, and pain. If infection occurs in a patient who has inserted a central venous cannula via peripheral vein puncture, it is recommended that the patient inform the attending physician in a timely manner and take relevant treatment measures. Patients can take oral antibiotics such as erythromycin capsules as prescribed by the doctor, and can also use injections of phenolsulfonyl ethylamine injection, tranexamic acid injection and other hemostatic drugs. When bleeding occurs after the use of peripheral venous puncture central venous catheterization, if there is no large amount of bleeding, no special treatment is needed. If infection occurs, the patient should consult a doctor in time and follow the doctor’s instructions for medication and treatment.