People who have cancer will certainly undergo many psychological changes, such as fear, pessimism and misanthropy, as long as very few people will feel that they are at the mercy of God and do not care. Therefore, psychological treatment should be based on certain skills, starting from details, discovering patients’ negative and pessimistic emotions in time, relieving patients’ bad emotions, keeping patients optimistic and open-minded, and letting patients fully understand the degree of development of the disease if necessary, so that patients can have a good state of mind to fight with the disease, improve the quality of survival and prolong the survival time. Objective analysis and understanding of patients’ psychological reactions, and adoption of targeted interventions: 1. Pessimism and disappointment: Once patients know they are diagnosed with cancer, they will become pessimistic and disappointed, lose their expectation of everything, as if death is just around the corner, fail to face the reality correctly, lack the mentality of active treatment, feel restless and hesitant. Therefore, after the diagnosis of cancer, family members and friends should grasp the patient’s psychological activities in time and seize the opportunity to provide psychological guidance to the patient, so as to eliminate the patient’s pessimistic mood. They should actively seek help from medical experts and let them introduce the characteristics of the disease and various effective treatment methods to the patient, and let the cured patient enlighten them if necessary, so as to stimulate the patient’s optimism and self-confidence, treat the disease correctly, get encouragement in the spirit and see hope in the treatment. 2. Pessimistic psychology: Once a patient learns that he or she has cancer, his or her relatives and friends will feel sympathetic and visit him or her with a feeling of pity, and even have a feeling of looking at him or her. In this perverse environment of care, the patient will think that the disease is serious and aggravate the pessimism, forming a “vicious circle” that makes it difficult for the patient to extricate himself or herself, and may even drive the patient to despair. Therefore, it is important to stop caring for the patient. Friends and relatives should not care about the patient with pity, but should be caring and considerate everywhere, and constantly eliminate the patient’s pessimism. Do a good job of mobilizing the patient’s relatives is the key step to reverse the patient’s pessimism poly. 3.Psychology of fear: People in general have different degrees of one-sided understanding of cancer and have the psychology of fear, which can be called “talking about cancer”, considering cancer as “terminal disease”, or even considering cancer as “a death sentence with suspended execution”. They even think that cancer is a “death sentence with a stay of execution”. For cancer patients who are introverted or highly nervous, they should be kept moderately secretive if necessary to avoid excessive tension and fear. For patients who already know they have cancer, they should be given scientific explanation, comfort and encouragement so that they can treat the disease correctly. For negative and disappointed patients, we should analyze the reasons, do a good job of psychological consolation, do a good job of regulating spiritual and life guidance, the importance of comprehensive cancer treatment, the dynamic role of will and emotion in curing the disease, and exclude the relevant psychological and social factors that are not conducive to treatment. 4.Suspicion psychology: Before cancer patients are diagnosed, they may have suspicion psychology and always think that they cannot be cancer and seek for medical help everywhere, and even pray to God and Buddha, instead of treating the disease with scientific attitude and delaying the treatment for months. With the development of science and technology, cancer in general can be diagnosed. Therefore, patients who suspect cancer must go to a large hospital or a medical specialist to get a clear diagnosis and treatment as early as possible.