At present, intramuscular injection of progesterone is still the most common route of administration for luteal support after in vitro fertilization-embryo transfer (IVF). Because progesterone injection is an oil, it is difficult to inject, and long-term intramuscular injection often causes local sclerosis with redness, swelling, pain, itching and other adverse reactions, which on the one hand causes pain to the patient, and on the other hand affects the absorption of the drug, which in turn may lead to lower pregnancy rate and higher early abortion rate after successful implantation. How to prevent hard knots can be done by gently patting the injection site several times before the injection, using local muscle relaxation while promoting accelerated local blood flow. 2-3 h after the injection (because it takes 2-3 h for the needle eye to close completely after the injection) you can apply hot compresses to the injection site to improve blood circulation, promote the dissipation and absorption of the drug, and prevent the possibility of hard knots. Already occurred hard nodules, can be treated by the following methods: 1, hot towel wet compress: This is our most common method, but also the most convenient and effective method. Patients can use a warm towel to apply to the injection site for 30-60 minutes, 2-3 times/day, 2-3 hours after the daily intramuscular injection of progesterone. Be careful not to apply hot compresses immediately after the injection, because the eye of the needle needs 2-3h to close completely, immediate hot compresses will cause extravasation of the drug or microbial entry, causing redness, swelling, itching and other inflammatory reactions! 2, potato slices (potato slices) paste: with fresh potatoes washed and cut into 1 ~ 50px after thin slices covered with intramuscular injection, with adhesive tape fixed, external potato slices help to relieve the local hard knots caused by intramuscular injection of progesterone, and has anti-inflammatory, pain relief, blood circulation and swelling function. Be sure to wash clean to prevent infection! 3.Chinese medicine external application method: Because rhubarb has the function of activating blood and dispelling silt, and mannite can clear heat and reduce swelling when used externally, so for large and hard nodes, Chinese medicine can be used: rhubarb 50g, mannite 50g, prepare dry and research into froth, then add vinegar and apply externally to the hard nodes. (Please use under the guidance of a doctor) 4.Onion juice plus honey treatment method: first wash the hard nodes with warm water and wipe dry. Use cotton swab to dip onion juice and honey to apply on the hard nodes, the area of application is slightly larger than the area of red and swollen hard nodes, 4 times/day. 5.Esalacridine lactate is applied topically on the affected area: put the gauze into 0.1% Esalacridine lactate and soak it in wet, the thickness of gauze is 3~4 layers, wring it half dry and then put it on the affected area, change it once every 10min for 30min, twice a day, 10 days is a course of treatment. (Please use under the guidance of a doctor) 6, TDP irradiation method: 30 minutes after intramuscular injection using TDP irradiation injection site, 2 times a day, 30 minutes each time, 10 days for a course of treatment. When irradiation first hit the TDP lamp, preheat 5 minutes, the timer will be rotated to 30 minutes, expose the gluteus maximus muscle directly irradiate the muscle injection area, irradiation distance of about 750px or according to the patient’s perception of heat distance, the skin feels the temperature of 40 degrees for the best treatment effect. (Please use under the guidance of a doctor)