It is best not to drink alcohol while taking anti-inflammatory medications, as drinking alcohol may cause the medication to become less effective and interfere with the healing of inflammation. Furthermore, drinking alcohol while taking anti-inflammatory drugs may increase the risk of adverse drug reactions, especially gastrointestinal symptoms, including nausea, abdominal discomfort, and loss of appetite. In addition, it may also increase the risk of developing drug allergies, and patients with inherent abnormalities in liver function are more likely to experience significant impairment of liver function if they drink alcohol while taking anti-inflammatory drugs. And some anti-inflammatory drugs during the use of alcohol, may lead to acetaldehyde poisoning and disulfiram reaction, including cephalosporins, and metronidazole, ketoconazole and other drugs. During the taking of these drugs certainly can not drink alcohol, or may cause disulfiram reaction, serious and even life-threatening.