Creatinine 100 μmol/L lasts for different durations depending on the type of disease, long enough to last a lifetime, short enough that it may persist for a few years, and in some cases, it may even progress quickly to uremia. Blood creatinine is a metabolic waste produced by the body and excreted through the kidneys. When the kidneys are damaged, the excretory function is reduced and the creatinine level in the blood is elevated. It is generally used as an important indicator for assessing kidney function. The normal range is 53~106μmol/L for men; 44~97μmol/L for women, with slight variations in the reference values in different hospitals. Creatinine 100μmol / L may be physiological factors such as eating a lot of meat, strenuous exercise, muscular athletes, etc., most of the renal function is normal, therefore, creatinine may adhere to the lifelong not rise. If creatinine 100μmol/L is caused by acute factors, such as diarrhea, gastrointestinal bleeding, urinary tract obstruction, etc., it can generally be reduced to normal after controlling the primary disease and may be maintained for a lifetime; however, if it is caused by systemic lupus erythematosus, vasculitis, it may persist for only a few years, that is, it will be developed into uremia stage. If it is caused by chronic factors such as hypertension, diabetes mellitus, chronic nephritis, the creatinine can be controlled at the same time of treating the primary disease, which may last for several years or even decades without progress. Patients with elevated creatinine are advised to consult regular hospitals and standardize treatment under the guidance of doctors.