(1) Skin changes: TSC has typical skin changes, such as depigmentation, shark leather spots, facial angiofibromas and perineural fibromas. (2) Neurological changes: prominent clinical manifestations in pediatric and adolescent patients, the most common being epilepsy, and a variety of abnormal neurological manifestations may also be seen. (3) Pulmonary changes: In female patients, lymphangioleiomyomatosis (LAM) changes can occur, with clinical manifestations similar to LAM, respiratory distress often progressing, and later requiring lung transplantation. (4) Tumors: TSC often occurs with a variety of benign tumors, with renal angiomyolipoma being the most common. Occasionally, malignant tumors occur.