Tuberous sclerosis is an autosomal dominant disorder that can affect multiple systems of the body, and in the central nervous system, epilepsy is one of its common symptoms. Etiology: Gene mutations are the most common cause of tuberous sclerosis, and two different gene mutations have been identified, TSC1 gene is located at 9q34 and TSC2 is located at 16p13.3. Although both mutated genes in tuberous sclerosis have a high rate of spontaneous mutations, they are still inherited in an autosomal dominant fashion. If both parents have tuberous sclerosis present, the probability of reoccurrence in the child is 50%. Clinical manifestations: Tuberous sclerosis typically presents with a triad of epilepsy, mental retardation, and facial angiofibroma. 1. Epilepsy 80%-90% of children have seizures, mostly before the age of 2 years, with multiple seizure types. Mental retardation is present in about 60% of children, especially in those with onset before the age of 2 years, often in conjunction with epilepsy. In addition, motor and language delays, memory impairment, hyperkinesia, and aggressive behavior may also be present. Typical skin changes include depigmented spots, facial angiofibromas, finger (toe) nail fibromas, sharkskin-like spots, and sometimes coffee milk spots. About 70-80% of patients can find facial angiofibromas, which used to be sebaceous adenomas, but are not actually sebaceous glands, but are composed of blood vessels and connective tissue. Treatment: Medication, surgery, ketogenic diet. Patients who are not satisfied with medication may be considered for surgery after comprehensive evaluation. 1. To clarify the responsible epileptogenic lesion. In the central nervous system, tuberous sclerosis is a multifocal lesion, and it is important to clarify the responsible epileptogenic lesion. For those who cannot define the epileptogenic foci and have clinical manifestations of infantile spasms or Lennox-Gastaut-like seizures, partial or total corpus callosotomy can be performed to reduce the number of seizures and mitigate the degree of seizures according to the EEG results and the clinical manifestations of the patient. 3. Lobotomy, because the nodules in the brain of tuberous sclerosis usually occur in the temporal lobe, frontal cortex or subcortex, when the epileptogenic nodules cannot be clearly identified, a comprehensive assessment can be made according to the EEG and the clinical symptomatology of the patient, and lobotomy such as temporal lobe or frontal lobe can be performed without affecting the important functions. Ketogenic diet therapy: Ketogenic diet therapy can be tried if no surgical condition is available.