A grade 5 thyroid nodule is 80% or more likely to be cancer. Thyroid nodule grade 5 generally means that the nodule is with more than 4 malignant signs, especially with microcalcification or microfollicular nodule, the risk of malignancy is higher, and more than 80% of them may be cancer. However, further pathological tissue biopsy is needed to make a clear diagnosis, which is made by a professional doctor based on medical history, symptoms, signs, imaging results and pathological results. Thyroid nodule grade 5 needs to be treated with surgery, primary foci treatment, lymph node treatment in the neck, supplemented by postoperative endocrine therapy and radionuclide therapy. Daily attention to avoid emotional excitement, so as not to affect the hormone level, but also need to pay attention to light diet, pay attention to iodine intake, such as kelp and so on.