Some thyroid cancer patients can be determined by genetic testing to determine whether there is a gene mutation. If the result is reported as BRAF gene V600E wild type, it means that there is no gene mutation, but the specific result needs to be combined with the pathology examination to make a comprehensive judgment. BRAF gene V600E belongs to the gene locus that is most likely to cause mutations in thyroid cancer. However, the histopathological results indicate malignant lesions, which means that the corresponding thyroid cancer is not accompanied by gene mutation, and it is necessary to combine with the results of pathological examination and carry out standardized treatment under the guidance of clinicians. By checking the genotype, the development of thyroid cancer is judged at a deeper level, and the current results show that there is no gene mutation, and standardized treatment should be carried out under the guidance of clinicians.