Diffuse midline glioma grade IV, because of its malignancy is already relatively high, and the survival rate is not very high, the prognosis is not good. For these patients, if surgery is available, it is recommended that surgery should be the main treatment, and surgery is very useful to improve the prognosis if total excision is possible. After surgery, radiotherapy or chemotherapy is recommended, the main purpose of which is to delay the survival rate of the patient, and also to assist in Chinese medicine, biological therapy, gene therapy and other comprehensive treatment-based methods. Because grade IV gliomas are more malignant and prone to recurrence, a combination of therapies is used to improve the survival rate of the patient, and regular review is required after surgery, in combination with relevant combination therapy measures.