A high risk of trisomy 21 indicates that the baby may have Down syndrome, which is not very common. Women need to undergo Down’s screening or non-invasive DNA in the middle of pregnancy, which can screen for chromosomal abnormalities in the fetus. A high risk of trisomy 21 indicates that the fetus may be Down’s syndrome. Such a child will be born with abnormal mental development, which is a great harm to the family and the child himself. A diagnosis of high risk for trisomy 21 is still relatively rare. Screening for a high risk of trisomy 21 is not 100% accurate, so amniocentesis is usually required for prenatal diagnosis to confirm the diagnosis. If the amniocentesis results are normal, the pregnancy can continue, but if the results are abnormal, the pregnancy should be terminated. It is important for pregnant women to have a good maternity checkup during pregnancy and seek medical attention if there is any abnormality.