For this reason, it is necessary to tell patients objectively “Does gastroscopy hurt?” For sure, neither painless gastroscopy nor ordinary gastroscopy will be painful, nor is it possible to be painful; unless the beginner enters the mirror roughly and directly bruises the mucous membrane of the pharynx, even if the mirror enters and bruises the mucous membrane of the digestive tube below the pharynx, there will be no pain phenomenon. Of course, gastroscopy as an invasive examination, the hose of the gastroscope to be from the patient’s mouth through the pharynx into the esophagus, into the gastric cavity, up to the duodenum, to complete the gastroscopy, more or less there is some discomfort is objective. For those patients who are nervous, sensitive and uncooperative pharyngeal vagus nerve and linguopharyngeal nerve, the gag reflex (nausea, vomiting) is more obvious when entering the pharynx; for those who are sensitive to gas, the gastroscopy may show a transient bloating phenomenon when the gas is injected to expand the gastric cavity due to the comprehensive observation of the various parts of the stomach. Other than that, there is no discomfort. In addition, today’s electronic gastroscopy, fine diameter, flexible; skillful operation (general gastroscopy as long as 2-3 minutes to complete the examination); preoperative with the relevant preparations (such as pharyngeal anesthesia to eliminate the gag reflex, or intravenous application of imipramine, isoproterenol, etc. to perform a brief general anesthesia, that is, painless gastroscopy or anesthesia gastroscopy). The vast majority of patients often do not feel anything to complete the examination, painless gastroscopy is to sleep, the examination is complete, that there is no pain. Gastrointestinal disease or early gastroscopy, it must be the gastrointestinal tract disease “fire eye gold”.