Membranous nephropathy stage II 24 hours urine protein 3500mg, the treatment includes general treatment, symptomatic treatment, immunosuppressive treatment and so on. 1. General treatment: proper attention should be paid to rest, avoiding public places and preventing infection. Those who have stabilized the epidemic should have proper activities to prevent venous thrombosis. 2. Symptomatic treatment: if obvious edema occurs, thiazide diuretics such as hydrochlorothiazide can be used to reduce edema; valsartan and benadryl can be chosen for antihypertensive and urinary protein-lowering treatments; warfarin can be used for anticoagulant treatment. 3. Immunosuppressive therapy (1) Hormones and immunosuppressants: for patients with high urinary protein after at least 6 months of observation period of blood pressure and protein reduction or combined with severe symptoms and complications related to nephrotic syndrome, immunosuppressive therapy can be given, and the drugs can be chosen as prednisone acetate combined with cyclosporine, tacrolimus, and so on. (2) Other immunosuppressive treatment: patients with persistent non-remission can also choose rituximab, which can significantly reduce the proteinuria of the patients, but its long-term efficacy still needs further study. Membranous nephropathy patients should go to the regular hospital in time, under the guidance of the doctor for standardized treatment. The medication should be used according to the doctor’s prescription, do not self-medicate.