Connective tissue disease may cause sweaty hands. Connective tissue disease is a kind of rheumatic disease related to autoimmune dysfunction, which can cause multiple organs and systems in the body to be involved and damaged, and common connective tissue diseases in clinic include dry syndrome, rheumatoid arthritis, systemic lupus erythematosus, etc. Since connective tissue disease may involve all organs and systems in the body, it cannot be ruled out that patients may have sweaty hands due to the disease. Since connective tissue disease may involve all organs and systems of the body, it cannot be ruled out that patients may have sweaty hands because of the disease, for example, connective tissue disease may bring sweaty hands when it causes fever symptoms, or when the disease leads to autonomic dysfunction, it may also lead to increased sweating, resulting in sweaty hands. Because connective tissue disease is a very diverse disease, and because each patient’s condition is different, the symptoms can vary significantly. Therefore, it is important for individuals to pay attention to their health condition and seek timely medical attention when they have any abnormalities, so that connective tissue diseases can be recognized and treated as early as possible, and the risk of the disease can be reduced.