Vomiting of intrahepatic bile duct stones may be caused by inflammatory stimulation, can be actively anti-emetic at the same time, anti-infective treatment, drugs including metoclopramide, cephalosporins and so on. Vomiting caused by intrahepatic bile duct stones can take metoclopramide, ondansetron and other drugs for antiemetic treatment, in addition, scopolamine and other drugs for antispasmodic treatment. In addition to antiemetic and antispasmodic, antibiotics such as ceftriaxone and cefoperazone are needed to control inflammation and improve symptoms. Due to individual differences, the drug is not absolutely effective and safe, it is recommended to strictly follow the doctor’s instructions to standardize the use of adverse reactions to timely access to medical care, drug allergy is prohibited. If medication is ineffective, surgery can be used to remove the stones and improve clinical symptoms and prognosis.