Thyroid nodules with clear borders and uneven internal echogenicity are more likely to be benign, but malignant nodules cannot be excluded and cannot be diagnosed by ultrasonography alone. Regular checkups, medication and surgery can be considered. If necessary, thyroid puncture biopsy can be performed to clarify the nature of the nodule. Thyroid nodules with clear borders and uneven echoes are a kind of manifestation under thyroid ultrasound, and clear borders indicate that benign nodules are more likely, while uneven echoes are considered to be changes in the thyroid parenchyma. If necessary, thyroid function tests should be completed, if accompanied by hyperthyroidism, you need to take methimazole and other antithyroid drugs, with hypothyroidism, you need to take levothyroxine sodium tablets. If the thyroid function is normal and the size of benign thyroid nodules is not large, regular checkups are sufficient and no special treatment is needed; if the nodule size is large and produces local pressure symptoms, such as dysphagia, dyspnea and so on, then surgical treatment needs to be considered. In the case of thyroid nodules with clear borders and uneven echogenicity, it is recommended to go to the hospital and ask the doctor to make a judgment and give a treatment plan.