Subcutaneous fluid accumulation in the wound after craniotomy is a common complication of craniotomy. If the amount of subcutaneous fluid is relatively small, local pressure dressing can be applied and the cranial CT can be reviewed regularly to observe the change of the amount of fluid. If the fluid gradually decreases, the treatment proves to be effective and the pressure bandage can be continued until the subcutaneous fluid is absorbed. If the amount of subcutaneous fluid does not change, or even becomes more and more, subcutaneous drainage can be done. A subcutaneous drainage tube is buried in the area where the subcutaneous fluid accumulates the most, and then an external drainage device is attached for continuous drainage, while the wound is dressed with local pressure and antibiotics are used to prevent infection. Most patients treated with these two methods will have the fluid gradually reduced and eventually absorbed.