After splenectomy, there may be some differences in immunity and blood system from normal people, but splenectomy generally has no serious adverse consequences on normal life activities and daily life of the human body. The spleen is the largest lymphatic organ in the body, and it plays an important role in the body’s anti-infection, producing specific antibodies, a variety of immune cytokines, and activated complements, as well as directly removing pathogens and foreign particles in the blood to perform the function of blood filtration. After splenectomy, the loss of the above functions, coupled with various local factors, the body’s ability to fight infection decreases, and various infections are prone to occur. The spleen is also part of the blood system, with hematopoietic function, blood filtration function, blood storage function, defense function, etc. When splenectomy is performed, the above functions may be affected in some ways. When a traumatic splenic rupture is removed when it cannot be repaired, some of the spleen’s functions can be replaced by the liver, bone marrow, lymph nodes, etc. When hypersplenism causes more harm to the human body, it is necessary to weigh the pros and cons and make a decision not to lose the good opportunity of surgery.