Generalized weakness and lumbago may be caused by physiological factors such as overwork or pathological factors such as low potassium and osteoporosis. 1. Physiological factors: frequent labor or excessive physical exercise can lead to muscle and soft tissue fatigue, excessive metabolic products in the body, lactic acid accumulation, resulting in generalized muscle pain and weakness, especially when bending over or bearing weight, lumbar pain will be more obvious, and can be relieved after rest. 2. Low potassium: when there is a large amount of potassium deficiency in the body, it has a great impact on the nerve function, which often leads to generalized weakness and back pain. 3. Osteoporosis: mostly occurring in the elderly, due to insufficient calcium supplementation or excessive loss of calcium, can lead to osteoporosis, clinical manifestations of generalized weakness, low back pain and joint pain symptoms. Generalized weakness and low back pain may be caused by other factors, such as symptoms continue to be unrelieved, it is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease for standardized treatment.