Hepatitis B vaccine can be given during menstruation, but it is recommended to avoid vaccination during menstruation to avoid aggravating menstrual discomfort. Hepatitis B vaccine is a special medication to prevent hepatitis B. The vaccination will stimulate the body’s immune system to produce protective antibodies, which will serve to prevent hepatitis B infection. Women can receive hepatitis B vaccine during menstruation, and menstruation is not a contraindication to hepatitis B vaccination. However, clinically it is generally not recommended for women to be vaccinated during menstruation because the resistance of women during menstruation is weaker, and they may also suffer from abdominal pain, headache, fatigue, etc. At this time of hepatitis B vaccination, the adverse reactions such as fever, nausea and abdominal pain may aggravate the symptoms of discomfort during menstruation. It is recommended that women receive the hepatitis B vaccine after menstruation, and stay in the hospital for observation for half an hour after vaccination, so that allergic reactions can be handled in a timely manner. After vaccination, if there are redness, swelling, hard nodules at the injection site as well as fever, nausea, loss of appetite, abdominal pain, etc., it is an adverse reaction of the vaccine, which can be relieved on its own in about 3 days.