Rabies, also known as hydrophobia, is a human-animal infectious disease caused by rabies virus invasion of the central nervous system with fear of wind, fear of water, pharyngeal muscle spasm, progressive paralysis as the main clinical manifestations, usually transmitted to humans by the saliva of sick animals in the form of bites, has not found evidence of human-to-human transmission, no special treatment, the death rate of 100%, so “prevention is important “. In order to prevent the onset of the disease, it is important to first understand its transmission route and mode of infection. The virus is mainly transmitted through bite wounds, but also by the saliva of the dog with the virus through various wounds and scratches, licking the mucous membrane and skin invasion, a few can be infected during the slaughter of sick dogs, skinning, cutting; in the bat colony cave because of the inhalation of aerosols containing the virus can also be infected, and organ transplants (such as corneal transplants) can also be infected. Whether or not the onset of disease after a dog bite is related to the following factors: 1. Bite site: head, face, neck, finger bites have more chances of onset. Remember: rabies virus is a neurophilic virus, so the closer the bite to the nerve center, the more chances of morbidity, the shorter the incubation period, children have a higher incidence rate because they are not as tall as adults 2, the extent of the bite: the incidence rate of those with deep and large wounds is high 3, local treatment: the bite quickly and thoroughly cleaned less chance of morbidity 4, timely, full and adequate injection of rabies vaccine and immunoglobulin low morbidity 5, the victim’s immune function is low The incidence of rabies vaccine and immunoglobulin is low in those who have been bitten, have low immune function or have immunodeficiency, and have a high chance of incidence. Smoking and drinking during vaccination may also reduce the immune effect. 4. Full vaccination and anti-rabies serum injection.