Elevated indirect bilirubin actually involves the problem of bilirubin metabolism, if the test value found that indirect bilirubin is mainly elevated, and elevated higher, the most critical factor is the increase in red blood cell cracking, the liver cells are too late to remove the cracked red blood cells, the problem occurs. Elevated indirect bilirubin suggests the possibility of intravascular hemolysis or other hemolysis, hemolysis is divided into acute hemolysis and chronic hemolysis, such as newborns can be born after the rise of indirect bilirubin, such as neonatal jaundice in such patients. If neonatal jaundice is not treated in time, there may be encephalopathic reactions, which may affect the intelligence of the newborn. It may resolve with later developmental improvement. There are also clinical medications that may cause an increase in erythrocyte cracking and an increase in indirect bilirubin. Genetic and metabolic disorders may also cause increased red blood cell destruction, resulting in elevated indirect bilirubin.