Severe pancreatitis care need to pay attention to: 1, bed rest, you can take the position of bending the waist and knees, or side lying position to reduce the patient’s pain; 2, strengthen the safety work, prevent patients from falling out of bed, reduce the patient’s psychological burden, close observation of the patient’s vital signs, observation of the patient’s urine output, especially in the liquid resuscitation, pay attention to the observation of the patient’s cardiorespiratory function, urine output, in order to control the speed of replenishment of fluids; 3, Patients with nausea and vomiting need to be fasted, and the diet can be opened gradually after the condition improves. For the combination of impaired consciousness, as well as infectious shock, should promptly establish intravenous access, ready to rescue drugs. If complications occur in the late stage to do a good job of preoperative preparation, intraoperative communication; 4, postoperative care related to severe pancreatitis, pay attention to severe pancreatitis has a lot of complications, such as can occur pancreatic encephalopathy, the patient will suddenly appear to change consciousness, irritability, with psychiatric symptoms, we must pay attention to the patient’s oxygen saturation in time, as well as the need for endotracheal intubation, or external respiratory improvement of the symptom.