There is no such thing as the best remedy for popliteal cyst. The treatment of popliteal cysts mainly includes general treatment, surgical treatment. 1. General treatment. Smaller popliteal cysts are mainly treated for symptoms of pain and swelling. You can use knee compression bandage, ice packs and so on. Can use puncture drainage, ultrasound-guided puncture injection of cortisol, etc. to reduce the cystic fluid, reduce the symptoms of swelling is also effective, mainly for cysts with more fluid. 2. Surgical treatment. Commonly used surgical treatment such as minimally invasive direct excision. It is mainly suitable for those cysts with large size or difficult to absorb and the effect of conservative treatment is not good. If popliteal cyst is diagnosed, it should be treated scientifically under the guidance of a doctor.