Sleeping at night with sore and swollen arms can be relieved by the following methods: First, if the upper limb muscles are severely strained resulting in local bruising, causing soreness and swelling and uncomfortable, the symptoms can be relieved by hot compresses and massage therapy, and the symptoms will be gradually relieved after about 30 minutes of treatment. Secondly, if it is an acute attack of cervical spondylosis, which causes the patient’s upper limbs to be sore, swollen and uncomfortable, traction treatment of the cervical spine is needed, together with ultrashort wave treatment and non-steroidal anti-inflammatory drug treatment, such as celecoxib capsules and loxoprofen sodium tablets. After the above comprehensive treatment, the inflammation and edema of the nerve will gradually subside, and the symptoms of soreness and difficulty in the upper limbs will be satisfactorily relieved. Therefore, choosing the appropriate treatment according to different etiologies can lead to the smooth relief of the above clinical symptoms. Attention should also be paid to the protection of muscles and cervical spine to avoid the above symptoms in normal times.