Numbness in the big toe can be caused by the following: first, toe neuritis and toe neuroma. These two diseases are often caused by inflammation and tumors in the toe nerve of the big toe, resulting in numbness of the bunion, which should be diagnosed by early physical examination and early neuromyography. Second, peripheral nerve compression, when the sensory nerve innervating the big toe is compressed at its travel, there can be symptoms of numbness of the big toe, which can be accompanied by pain, then early physical examination, electromyography of the lower extremity, and if necessary, ultrasound or MRI to diagnose and treat. Third, the pear-shaped muscle syndrome, pear-shaped muscle syndrome can compress the sciatic nerve and lead to symptoms of bunion numbness, this time to early physical examination, check the sciatic nerve electromyography to diagnose. Fourth, lumbar spine diseases, lumbar spine with lumbar disc herniation or lumbar spinal stenosis can compress the nerve roots, resulting in symptoms of numbness of the big toe, then we should check the lumbar spine CT, MRI to diagnose and early treatment.