Mannitol once the leakage occurs to immediately replace the infusion site, and for the degree of injury to choose different treatment methods: First, hot compresses, to promote extravasation in the tissue of the liquid dissipation and absorption. 20% of the mannitol leakage caused by tissue damage can be used 654-2 wet compresses, with Phentolamine sealing the effect of the local, but also can be used in 50% of the magnesium sulphate wet compresses. Second, closed therapy. Closed injection can prevent the combination of drugs and tissue cells, commonly used 0.25% procaine or saline local closure. Thirdly, some methods of removing blood stasis, activating blood circulation and reducing edema are used. It has better effect on edema, blood stasis and pain caused by drug leakage. Fourth, irradiation therapy can be used, using infrared radiation to dry the local tissues.