The more serious signs of stomach cancer in advanced stage include abdominal pain, abdominal distension, nausea and vomiting, vomiting blood or blood in stool, serious tumor rupture and perforation, etc. Wasting, severe anemia, fever and shock may also occur. When stomach cancer develops into advanced stage, there may be pain in upper abdomen, acid reflux, nausea and vomiting, and in serious cases, there may be vomiting blood or blood in stool, etc. It may be caused by rupture of tumor of stomach cancer, and individual patients may have perforation of stomach, which is a serious sign of stomach cancer in advanced stage. Systemic symptoms such as emaciation, fatigue, severe anemia, fever and shock may appear in late stage of stomach cancer, which are also more serious signs. It is recommended to go to the hospital in time to get a clear diagnosis and active treatment for advanced stomach cancer.