Special forgetfulness may be caused by mental tension, stress, or lack of sleep. To relax, reduce stress, develop good habits, sleep on time, get up without staying up late, and ensure sufficient sleep time, may also be a manifestation of pre-Alzheimer’s disease, mostly seen in middle-aged and elderly people, patients mainly show near memory impairment, but relatively preserved for distant. In the early stage, drugs to improve brain metabolism and improve blood circulation can be applied, commonly used are Olacitant, Piracetam, Cytarabine, Cerebrolysine and Vincristine, and drugs to improve blood circulation mainly include Shuxinin, Sparing Blood, and Verbascan, and also oral Danshen, Panax notoginseng, Safflower, and Ginkgo biloba drops, which may slow down the progress of the patient’s disease. Patients should be instructed to relax, reduce stress, communicate more with people, participate in more social activities, do more hands and use more brains, which may also slow down the progress of the patient’s condition, and if necessary, oral donepezil and staphylocarpine A can also be taken.