Immune tolerance is a concept in medical immunology that refers to the inability of the body to develop immune reactivity (antibodies or sensitized lymphocytes) to certain substances (antigens) that are immunogenic, i.e., the inability to produce the desired repulsive response to the substance, at a particular age and state of the organism. The most direct observation of this phenomenon comes from the human body, where no individual produces an immune response to its own tissue components, even though these constitute antigens to other individuals and induce a corresponding immune response. The former is the phenomenon of immune tolerance, while the latter is the phenomenon of rejection. According to immunological principles, immune tolerance to one’s own tissues is developed very early in an individual’s development, and the advantage of this is obvious: the body’s immune system is not capable of generating a rejection reaction against its own tissues, thus avoiding accidental injury to itself. If this immune tolerance is altered to produce an immune response to self-tissue components, autoimmune diseases such as systemic lupus erythematosus may result. There are a number of theories as to how the body’s immune system develops an immune tolerance to its own tissue components. One of the most important is the “asexual line deletion” theory. According to this theory, the immune system is exposed to an overwhelming number of self-tissue antigens in the very early stages of an individual’s development, which results in the “deletion” of immune cells directed against these self-tissue antigens, and the body develops tolerance to the self-tissue antigens. If the body’s immune system is not exposed to these self-tissue antigens at the right time, subsequent exposure to these tissue antigens can result in an immune response that targets the self-tissue for attack or rejection by the immune system. For example, some components of the human eyeball are wrapped up and isolated from the body’s immune system before the formation of immune tolerance, and after being exposed to the body’s immune system as a result of trauma and recognized as antigens with “foreign body” characteristics, the body’s immune system will have an immune and rejection reaction against the components, resulting in corresponding inflammation and necrosis. The body’s immune system then reacts not only against the injured eye, but also against the same tissue components in the uninjured eye, resulting in inflammation and necrosis in the uninjured eye as well. This is an important reason why ophthalmologists advocate the removal of the injured eye in patients with monocular injuries, primarily to avoid the involvement of the healthy eye due to the immune response. It can be seen that the immune system’s exposure to and recognition of the body’s own tissue antigens occurs at a “very early and appropriate stage” of an individual’s development, and after the formation of immune tolerance, there is no longer an immune response to the body’s tissue antigens, and those who miss this “very early and appropriate stage” are then exposed to the immune system’s immune response. “Those self-tissue antigens that are missed and then contacted by the immune system are recognized as foreign by the immune system and are attacked and rejected. Similarly, the “overwhelming number” of self-tissue antigens at this “appropriate very early stage” is an extremely important condition, and if the number does not reach an overwhelming level, it may not lead to the deletion of immune cell lines (clones) against self-tissue antigens. This is an important basis for self-protection of the organism, otherwise the formation of an immune response against the antigens of its own tissues will lead to the premature death of the individual in the very early stages of its life. Hardiness is a term that describes a person’s ability to endure hardship and work hard. Although hardship and hardiness are not identical traits, they may indeed be causative and mutually reinforcing. The formation of immune tolerance in medicine depends on the body’s immune system being exposed to an “overwhelming amount” of self-tissue antigens at an appropriate and very early stage, and the formation of the ability of human beings to withstand pain and hard work is not formed through intentional or unintentional training at an appropriate and “very early stage” of life. How is it that the human ability to withstand pain and toil is not formed through intentional or unintentional training at a very early stage of life? As the most complex organism in the world, all the physiological, psychological and behavioral development of human beings is similar to the formation of immune tolerance, with the formation and establishment of certain appropriate adaptive abilities and mechanisms at the “right” age. For example, the ability to tolerate pain, or the ability to suffer, should also be established and formed at a relatively early age. In childhood, if an individual experiences relatively frequent or sufficient “suffering” in his or her life, it may be something that has an important impact on his or her life – suggesting a comparable “level of suffering” for him or her at a later stage of his or her life. Suggests a comparable frame of reference for “levels of suffering” at later stages of life. Physiologically, a child who has been trained to “suffer” physically establishes a frame of reference for the degree to which he can physically tolerate pain, i.e., within which he can tolerate physical pain and will not experience unbearable pain as a result of suffering. There is some supporting evidence for this in physiology. Psychologically, a child who has undergone the appropriate “suffering” training will also develop a corresponding reference system for suffering, and will not experience intense unbearable pain for pain less than this level. This is the reason why those who can suffer can endure labor. Of particular concern is that suffering in childhood, whether it is physical or psychological suffering, has a good adaptability because it is at this particular age, and unless it is abusive, it will help them to develop a good capacity for suffering and endurance, and ultimately to develop good physical and psychological qualities. Why does suffering in childhood not harm them? First of all, due to the active behavioral characteristics of individuals in childhood, they are easily attracted by fresh things around them in daily life, and in the process of their experiencing suffering because their interest in other fresh things has not disappeared and they have not stopped exploring fresh things, thus they are easy to transfer their experience of suffering and fade away the experience and memory of the suffering brought about by the previous thing, and it is often not easy to cause lasting damage to the psyche. Moreover, because exploring new things is more likely to bring pleasure or joyful experience, children are more likely to use the current happy experience to “shield” the previous painful experience, or use the current happy experience to “beautify” the previous painful experience, so that the painful experience will be further Reduced. I remember that during the Cultural Revolution, because of my family background, I was always excluded by the “Red Guards” or the “Red Guards”, and I was even subjected to intentional or unintentional contempt and other injuries from classmates and neighbors who knew my family background. But because we didn’t need to go to school regularly at that time, and we spent the whole day “playing wildly” in adventurous activities up the mountains and down the rivers with some friends who shared the same hobbies, these happy memories gradually overshadowed, faded out, and even embellished my memories of those unhappy experiences, and whenever I recalled my own childhood life, more and more beautiful experiences emerged in my mind! . Secondly, due to the low level of individual cognition of the colorful world in childhood, which is equivalent to a blank sheet of paper, it is extremely easy to be influenced by adults’ or partners’ cognition and description of the world and make their own cognition change. If a child grows up with adults (including parents and teachers) and peers whom he trusts and who often draw his attention to the innocence, beauty, and goodness of the world, it is naturally easy for him to form positive perceptions of the world and to generate happy emotional experiences and positive behavioral responses. Even if in real life there is no lack of opportunities for him to suffer trauma and frustration, as long as he is more actively given the opportunity to allow himself to experience happiness, then the risk and extent of his psychological damage will be greatly reduced. If the influences he receives throughout his formative years as a child and adolescent come from such positive cognitive activities, he will naturally develop a corresponding positive cognitive pattern, and eventually form a positive attitude towards life, and will not lose confidence in the future because of one-off setbacks. Besides, the poor children will be the first to become a family. Due to the poor economic situation of their families, children growing up in poor families experience some psychological or physical “pains” earlier than their peers in good economic conditions, for example, they may not enjoy the carefree material life of “having food on the table and clothes on the table”, and even their diet is lower than that of their social counterparts. For example, they may not be able to enjoy a carefree material life where they have to pay for their food and clothing, or even have a diet that is below the average standard of society, let alone the luxury of owning high-quality toys, or even have to help their parents with household chores or do their bit to support the family’s livelihood. When suffering that is too much for other children of the same age to bear becomes a normal part of these children’s lives, then they don’t think of it as suffering. This is especially true if the parents are psychologically sound, have a positive outlook on life, and are happy to live in poverty, which can have a positive impact on their children. When such children take on responsibilities that others of their age cannot, if their parents recognize this with appreciation, encouragement and even gratitude, it will undoubtedly make the children feel proud of themselves and become the motivation for healthy growth in the future. If parents can also use the “Q spirit” to appease the children’s sense of loss due to comparison with others in material enjoyment, so that they can learn to self-motivation, it will be more conducive to the happy growth of these children. Moreover, children who grow up in day-to-day misery, once they have the opportunity to enjoy a short period of time when they do not have to endure such painful labor or life, they will treasure such time. To put it in medical terms, it can be argued that children from poor families have a higher “threshold” for suffering and are less prone to pain, and a lower “threshold” for happiness and are more likely to be happy.