Diarrhea may cause kidney injury, but generally caused by pre-renal kidney injury, the injury is generally reversible after timely rehydration and other treatments. Diarrhea, i.e. diarrhea, can be divided into acute diarrhea and chronic diarrhea, manifested as an increase in the volume and frequency of defecation, stools are not shaped, and viral, bacterial, fungal infections such as ischemia, allergies, radiotherapy and other factors, which can lead to dehydration and other symptoms of the patient. Increased loss of water from the intestines during diarrhea results in insufficient intravascular water, causing blood volume insufficiency and contraction of the bilateral renal arteries, leading to insufficient renal perfusion. If the bilateral renal arteries are contracted for an excessive period of time, it will lead to ischemic injury of the kidneys, and the local metabolites, such as lactic acid and oxygen radicals, will attack the kidneys, causing acute kidney injury. Acute kidney injury manifests itself as a decrease in glomerular filtration rate, accompanied by retention of nitrogen products such as creatinine and urea nitrogen in the body, disturbances in water, electrolyte and acid-base balance, and symptoms such as oliguria and anuria. Diarrhea patients are recommended to seek timely medical attention to clarify the diagnosis, under the guidance of the doctor for targeted treatment.