The phenomenon of acne breakout after topical application of adapalene gel is actually a normal phenomenon, because this cream may cause short-term skin irritation, and after the first 1-2 days of use, the original acne lesions may be aggravated, which is a normal reaction to the drug, not due to the aggravation of the disease after the drug has been used. When patients use adapalene gel for treatment, the main purpose is to provide anti-keratinization and anti-inflammation. When it is first used in the early stage, the local skin stratum corneum may dissolve, and after dissolving, it may cause local lesions to form corresponding irritation and eventually form inflammatory aggravation.