For bone pain caused by multiple myeloma, NSAIDs and bisphosphonates can be used for treatment. 1. When patients have pubic bone pain due to multiple myeloma, they can use NSAIDs for analgesic treatment, such as celecoxib and ibuprofen. 2. Some bisphosphonates can also be used, such as zoledronic acid, which can inhibit the activity of osteoclasts, repair the patient’s bone destruction, and reduce pain. In addition, the etiologic treatment of multiple myeloma is needed, and the drugs include bortezomib and lenalidomide. Multiple myeloma is a malignant proliferative disease characterized by massive proliferation of monoclonal plasma cells in the bone marrow, which often leads to anemia, hypercalcemia, renal impairment, and is most typically characterized by bone damage and bone pain, which commonly involves the lumbar, sacral, and pubic bone areas. Multiple myeloma pubic bone pain is recommended to be treated under the guidance of specialists, avoiding self-medication.