Head pain one year after craniotomy for brain tumor may be incision site pain, tumor recurrence, craniocerebral injury syndrome, which can be treated by medication according to different causes. 1. Pain at incision site: if pain persists one year after craniotomy for brain tumor, it may be caused by poor healing of incision site. A few patients will have postoperative localized incision site pain, which can be relieved by applying recombinant human epidermal growth factor to promote the growth of wound granulation tissue, together with pain relieving drugs, such as ibuprofen extended-release capsules. 2. Tumor recurrence: pain one year after craniotomy for brain tumor may also be tumor recurrence, in addition to the symptoms of headache, there may also be symptoms of increased intracranial pressure caused by occupying lesions, such as nausea, vomiting and so on. It is recommended to consult doctor in time. 3. Craniocerebral Injury Syndrome: generally refers to the after-effect phenomenon after craniocerebral injury for a period of time, which can be manifested as headache, dizziness, memory loss and so on. Betahistine, Loxoprofen, cytarabine sodium, ginkgo biloba, etc. can be used to protect nerve cells and reduce the symptoms of headache and dizziness. If the symptoms of headache after brain tumor surgery continue to be unrelieved, it is necessary to consult a doctor in time, under the guidance of a professional doctor to identify the cause of the disease and target treatment.