Infection with both Mycobacterium tuberculosis and non-tuberculosis mycobacteria is a more serious condition and requires active treatment as prescribed by the doctor. Mycobacterium tuberculosis is the main causative agent of tuberculosis, and once infected with Mycobacterium tuberculosis, tuberculosis toxicity symptoms may appear as progressive weight loss, fatigue, loss of appetite, anorexia of oil, and there may also be low afternoon fever, night sweats and other clinical manifestations. Non-tuberculous mycobacteria are infections with mycobacteria other than human, bovine, and leprosy bacilli that result in pulmonary or extrapulmonary disease. The infection is usually acquired from sewage or soil when resistance is low. It is severely damaging to lung and liver function, and also causes skin, lymphadenitis, bone and joint, and urinary tract lesions. When patients have the above symptoms, they should go to the hospital in time to identify the cause of the disease and then take targeted treatment.