Fever with hot hands and feet may be caused by qi deficiency, blood deficiency, yin deficiency, fire and heat within, it is recommended that patients go to the hospital for a clear diagnosis and treatment, the use of medication need to be under the guidance of a doctor, do not use private medication. 1. Qi deficiency: the patient’s lack of qi (weak spleen and stomach qi), yin and fire, which can be manifested as shortness of breath and laziness, drowsiness, low-grade fever, hand, foot, and heart fever, etc., can be treated with tonifying zhong yi qi tong plus subtractions, which has the efficacy of sweet and warming and removing heat (treating fever with sweet and warm herbs) under the guidance of a doctor. 2. Blood deficiency: the patient’s blood deficiency and yin injury, without convergence of yang, will lead to yang bias, yang has no attachment and floating scattered outside, can be manifested as pale lips and mouth, five heart heat (two hearts and two feet heart heat, and consciously heart and chest heat), hot flashes (a burst of heat) and other symptoms, can be under the guidance of the doctor with the tonifying qi and blood quan spen broth plus or minus treatment. 3. Yin deficiency: the patient’s body is deficient in yin fluid, and water cannot control fire, which can be seen in symptoms such as excessive thirst and drinking, facial flushing, night sweating, and heat in the hands, feet and heart, etc. The patient can be treated with Zhi Bai Di Huang Wan (知柏地黃丸) which has the efficacy of nourishing yin and clearing heat (nourishing the yin essence and clearing away the heat) with additional subtractions under the guidance of the doctor. 4. Fire-heat internalization: the patient’s excessive will, dietary disorders, etc. lead to fire-heat internalization in the body, which can be manifested as dry stools, short yellow urine, dry mouth and throat, generalized dryness and heat, hot hands and feet, etc., and can be treated with Huanglian Xieyue Tang with the efficacy of clearing away heat and fire under the guidance of the doctor. The above medicines should be used under the guidance of TCM doctors to avoid adverse effects.