Hand, foot and mouth disease is categorized into ordinary cases and severe cases, the treatment of the two is different, care should pay attention to avoid infecting others, light diet. 1. Ordinary cases: give antipyretic ibuprofen, acetaminophen and other control can be. 2. Treatment for patients with severe cases. (1) Those with neurological involvement should be given mannitol to control intracranial hypertension and furosemide if necessary. Use glucocorticoids such as methylprednisolone and dexamethasone as appropriate. (2) Treatment of respiratory and circulatory failure: timely use of tracheal intubation oxygen to maintain respiratory patency. At the same time detect heart rate, blood pressure and other vital signs. 3. Nursing methods: in the early stage of the disease is most likely to be infectious, should take timely isolation measures to prevent contagion, disinfection of the child’s clothing. Do a good job of oral care, oral herpes and ulcers are serious, rehabilitation of new liquid gargle or use a cotton swab on the affected area, after recovery, do not let the child share toys with other children with the disease or close contact, to avoid re-infection. Eat a light diet, do not drink raw water, do not eat cold food. If HFMD is diagnosed, it is recommended to isolate the child, consult a doctor in time and treat the disease actively.