Botox has been used in cosmetic wrinkle removal for more than 20 years, and has been ranked as the top cosmetic surgery procedure in the United States for many years. Principle of Botulinum toxin for wrinkle removal The main component of Botulinum toxin is highly purified botulinum toxin type A, that is, a type A toxin secreted by Clostridium botulinum in reproduction, which can inhibit the transmission of motor nerve impulses, and make the local muscles unable to contract, so as to remove the wrinkles. Because botulinum toxin mainly works with muscles, it is effective in removing wrinkles caused by muscle movement, i.e. dynamic wrinkles. Frontal lines, frown lines, crow’s feet, wrinkles on the back of the nose, corners of the mouth, perioral lines, etc., which only appear when we make facial expressions, can be removed with Botox at the initial stage. In addition, early neck wrinkles that occur because of frequent bowing of the head can also be removed with Botox. Is it effective to start taking Botox at the age of 20 to prevent wrinkles? In foreign countries, there are indeed women who do this. A Canadian woman started Botox at age 20 to prevent herself from getting wrinkles. Her goal was to wait until she was in her 50s if she had fewer wrinkles in key areas of her face and no too deep wrinkles between her eyebrows. Another person, who is prone to wrinkles because she has less fat in her face and can’t get them down once she has them, also chose to start Botox before the wrinkles appeared. Is prevention really effective? Not necessarily, because too much too soon may create resistance. When is the best time to start Botox? Some people will choose to get Botox injections to prevent wrinkles early on in their youth. In fact, it’s not necessary at all. Don’t use your age to gauge whether to get Botox or not, you can act when you get your first expression lines on your face. Generally speaking, crow’s feet and eye lines appear at the age of 25-28 years old, head lines, frown lines, and dorsal nose lines appear roughly at the age of 28-32 years old, and corners of the mouth and laugh lines appear at the age of 32-36 years old. Some people have expression lines earlier than average, not genetically, but certain expressions are born uncontrolled. For example, people who habitually love to make eyebrow lifting and frowning motions since childhood are more likely to have head or frown lines than the average person. Why does resistance develop? Wrinkles are an annoying sign of ageing and it is understandable to want to prevent them, but if you inject too much too soon, you may develop resistance. Because the effect of Botox is temporary, repeated injections are necessary. But the body’s immune mechanism to produce antibodies against foreign substances, with the application of vaccines to prevent viral infections, the same principle, so any agent as long as it contains proteins, the theory of long-term repeated injections, the human body may produce antibodies. In the past, botulinum toxin contained complex proteins, long-term overdose, will not be able to play a role in muscle relaxation. Manufacturers have also taken this into consideration, and today’s Botox places have removed the complex proteins during the manufacturing process, reducing the problem of resistance. But that doesn’t mean the problem is completely solved. If you’ve had multiple Botox injections and find that the results are not as good as they used to be, you should be wary: you may be developing resistance to Botox. How to prevent resistance? The body metabolizes Botox in about 3-6 months, with injections at least two months apart. If resistance to Botox has developed, after 2-3 years, the antibody effect will be reduced and from this point onwards Botox injections can be administered in a new way. No effect after Botox injection? Usually after playing botulinum toxin, the effect will not take effect immediately, but need to wait for it and muscle nerve action, about 5~10 days, the effect will be gradually obvious; if after half a month have no effect, then you may be encountered these problems: 1, botulinum toxin transportation and storage unqualified Botulinum toxin as a special preparation, in the transportation and storage has strict requirements, if the temperature of the storage is not suitable or packaging is not right may not be suitable. If the storage temperature is not suitable, or the packaging is not right, it is possible to make botulinum toxin inactivation, so as to lose its effect. 2, the doctor injects the wrong dosage and site Botox for the dose of the requirements are usually accurate to 2 decimal places, the requirements are quite high, the general internship or technical doctors are not good enough doctors are difficult to accurately achieve, which will make the Botox injection is too little and can not achieve the effect or injection too much to make the face stiff; the same, the injection site will also have a great impact on the final effect. 3, injection did not according to the doctor’s requirements recovery After injection of botulinum toxin, attention should be paid to the injection site in accordance with the correct postoperative maintenance care, otherwise it is easy to make botulinum toxin inactivity or early absorption by the body metabolized. Expression lines are a sign of aging skin, and aging, if left unchecked, will continue to develop rapidly. Faint wrinkles may give you a sense of flavor, a “sign of life”. However, there is no need to be overly concerned, follow the will of a professional doctor in a regular institution, according to the course of treatment and dosage, to find the balance point, to remove wrinkles while preventing drug resistance.