Low prothrombin time is commonly seen in a hypercoagulable state, such as in the early stages of DIC, myocardial infarction, or cerebral thrombosis. In addition, low prothrombin time can also occur in acute thrombophlebitis, multiple myeloma, digitalis toxicity, and after ether anesthesia. Measurement of prothrombin time is usually indicated for the following conditions: for people with ischemic heart disease and prosthetic valve use, such as for condition monitoring when taking oral anticoagulants, or to check if there is a decrease in vitamin K-dependent factors II, VII, IX, and X synthesized by the liver and if there is a vitamin K deficiency, and also for screening for liver disease, because liver disease, such as chronic liver disease, can lead to coagulation disorders.