Patients with chronic hepatitis B often regard the cure of hepatitis B as the goal of treatment, and painstakingly pursue “turning negative”, but in fact, this is unrealistic, with the current level of medicine, has not found a cure for hepatitis B. Chronic hepatitis B has the characteristics of recurrent onset and gradual progress, and the final outcome is easy to progress to cirrhosis or even liver cancer, and its development is irreversible. Therefore, the goal of treatment is to cure the current inflammation and prevent the recurrence of inflammation, thus stopping the progress of liver disease and reducing and preventing the occurrence of cirrhosis, liver cancer and complications. Patients with chronic hepatitis B can fully achieve the realistic goal as long as they have regular checkups, discover the onset and standardize treatment in time.