Atenolol and nifedipine can both be used in the treatment of high blood pressure disease, for grade 2 or higher high blood pressure is recommended to use a combination of drugs, the combination of drugs can better reduce blood pressure, but also offset the side effects of the drug. Adverse effects of Atenolol include hypotension, bradycardia, dizziness, cold extremities, fatigue, malaise, gastrointestinal discomfort, depression, alopecia, thrombocytopenia, rash, and dry eyes. It is contraindicated in patients with II-III degree heart block, cardiogenic shock, sick sinus syndrome and severe sinus bradycardia. Adverse reactions to nifedipine include hypotension, palpitations, chest tightness, shortness of breath, diarrhea, abdominal distension, inflammation of skeletal muscles, nervousness, stiffness of joints, muscle spasms and tremors. It is contraindicated in people who are allergic to this drug. During the combination of atenolol and nifedipine, it should be used under the supervision of a physician, do not increase or decrease the dosage on your own, in order to avoid adverse consequences.