The specific causes of uterine smooth muscle tumor are not clear, and the disease may be related to genetic factors, abnormal sex hormone levels, stem cell dysfunction and other factors. 1. Genetic factors: If there are patients with uterine smooth muscle tumor in their parents’ generation, their direct descendants will have a higher chance of developing the disease compared with normal people. 2. Abnormal sex hormone level: Uterine smooth muscle tumor is a kind of sex hormone-dependent tumor, which is related to excessive estrogen stimulation. Increased estrogen may cause myometrial cells to proliferate, hypertrophy, thickening of myometrium and enlargement of the uterus, especially when there is only estrogen but no progesterone. 3. Stem cell dysfunction: uterine smooth muscle tumors may also be caused by mutations in stem cells. It is recommended that people with the above high-risk factors should have regular medical checkups, and patients with long-term menstrual abnormalities and bladder emptying difficulties should consult a doctor in time, get a clear diagnosis after complete examination, and standardize the treatment under the guidance of a professional doctor.