What is the interpretation of myocardial injury markers

Myocardial injury markers mainly include glutamate aminotransferase (GOT), lactate dehydrogenase (LD), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), troponin, myoglobin. 1. Glutamine aminotransferase: It is elevated about 6-12 hours after the onset of acute myocardial infarction, peaks at 24-48 hours, and lasts for 5-7 days. However, it does not have tissue specificity, so its elevation alone cannot diagnose myocardial injury. 2. Lactate dehydrogenase: Continuous measurement of lactate dehydrogenase has certain reference value for patients with acute myocardial infarction who have been diagnosed late and whose creatine kinase has returned to normal. 3. Creatine kinase: it can be used to diagnose acute myocardial infarction, creatine kinase less than the upper limit of the reference value can exclude acute myocardial infarction, but should also be excluded from the myocardial injury and subendocardial infarction and other conditions. In viral myocarditis, creatine kinase can also be significantly elevated. 4. Creatine kinase isoenzyme: its sensitivity and specificity for the diagnosis of acute myocardial infarction are better than that of creatine kinase. 5. Troponin: Troponin is the first choice of diagnostic marker for acute myocardial infarction, and it can also sensitively reflect small focal and reversible myocardial injury, and it can also be used for the judgment of reperfusion after thrombolysis. 6. Myoglobin: the specificity is not high, other muscle injury, shock and renal failure can also be elevated. Myocardial injury markers for myocardial injury has a certain reference significance, but is not the “gold standard” for diagnosis, its indicators should be interpreted by a professional doctor.