The possible causes of esophageal erosion, bleeding and pain include esophagitis, esophageal leukoaraiosis, esophageal cancer, etc. The treatment measures include medication, surgery, radiotherapy and so on. 1. Esophagitis: It is necessary to treat the cause of esophagitis. In case of reflux esophagitis, acid-suppressing drugs such as omeprazole and rabeprazole, and gastric stimulants such as domperidone and mosapride can be used. In case of co-infection, anti-infective drugs such as clarithromycin, amoxicillin and metronidazole can be used to treat specific pathogen infection. 2. Esophageal leukoaraiosis: a series of drugs such as glucocorticosteroids like prednisone, immunosuppressants such as azathioprine or cyclophosphamide, biologics such as infliximab, and non-steroidal anti-inflammatory drugs such as celecoxib can be used for the treatment of esophageal leukoaraiosis. 3. Esophageal cancer: Surgery is the main treatment for esophageal cancer, and at the same time, cisplatin, paclitaxel and other drugs such as chemotherapy and radiotherapy can be supplemented. The above drugs need to be used under the guidance of clinicians and unauthorized use of drugs is prohibited. If symptoms such as esophageal erosion, bleeding and pain occur, it is recommended to go to the hospital for consultation in time.